Application Question
Medium difficulty • Concept in a practical situation
Question 1
Applied ConceptA doctor notices that a common antibiotic is no longer effective against a bacterial strain that was previously susceptible. With reference to Darwin's theory of natural selection, explain how this resistance could have developed.
- The bacterial population originally contained individuals with random pre-existing mutations, some of which happened to confer resistance to the antibiotic. These variants were present in small numbers before antibiotic exposure, as mutations are random and directionless.
- When the antibiotic was introduced, sensitive bacteria were killed, but the resistant variants survived and reproduced. Over multiple generations — which in bacteria can mean millions of individuals within hours — resistant variants outgrew the sensitive population, changing population characteristics drastically.
- This is a classic example of natural selection by anthropogenic action: the antibiotic acted as the selection pressure, and the heritable resistance trait was favoured. Evolution in bacteria occurs in months or years (not centuries) due to short generation times, explaining the rapid emergence of resistant strains.